Gamma-linolenic acid (GLA) includes can relax constricted coronary arteries by blocking a specific receptor, which may help prevent spasms and angina. Additionally, older research indicates GLA may contribute to cardiovascular health by reducing thromboxane and increasing prostacyclin production. Another significant 2023 finding highlighted GLA's essential role in heart metabolism immediately after birth by signaling the maturation of the heart's ability to use fat for energy. 

Cardiovascular health and heart function
Relaxing constricted arteries: A June 2025 study found that GLA can directly relax constricted coronary arteries by blocking prostanoid TP receptors, which are involved in blood vessel contraction. This is a new insight into how GLA may help prevent coronary spasms and angina.

Challenging a previous belief: The study suggests that GLA, an omega-6 fatty acid, has a vascular effect similar to omega-3s, which challenges the belief that only omega-3s have this vascular benefit.

Supporting heart maturation at birth: A 2023 study in Nature discovered that GLA, present in breast milk, is a key signal that activates the retinoid X receptor (RXR) in neonatal heart cells, triggering the genes needed for the heart to start using fats for energy after birth.